I haven't found a lot of info on Malta (or Gozo and Comino either) so I though we could use this thread as a depository for future Malta-goers.
First, I went there in May 2007 and the it was beautiful. I've never been anywhere like it. Definitely go to the Blue Lagoon on Comino as it is one of the most beautiful places I have ever seen. I also thought Valetta was very cool. The cathedral there is amazing!! You can definitely feel the British influence on the islands - it's kinda weird actually.
Here's some pics I took.
The Blue Lagoon (look familiar for you movie buffs?)
St. John Cathedral