The only disadvantage I can see is if you plan to walk around a lot with your suitcase, for example looking for a hostel with availability. The sidewalks, even in Bangkok, are very uneven, sometimes have big holes, are very cluttered with vendors, etc. Dragging your suitaces behind you may be an issue because of this. If you already have accomodation booked and just plan to take a taxi to/from your accomodation, I would say no problem. If you have to do it, though, no worries. You can manage, it just might be a pain at times. You may just become a bit more reliant on taking taxis or tuk-tuks, which isn't really a problem as they are generally cheap anyway. Good luck!!
"Those who would give up essential liberty to purchase a little temporary safety, deserve neither liberty nor safety." Ben Franklin
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